The Eagles lose a running back but get one back for “Thursday Night Football” in Week 6, while the Giants thought they could have their starting tight end back in the fold until he missed practice on Wednesday and was ruled out.

We’ll break down the injuries you need to know about for that matchup below before digging in to each team playing on Sunday’s initial injury report for Week 6. Check back with us throughout the day as we react to all the injury news around the NFL.

Eagles (-3) at Giants

The Eagles are hurting at two key positions: running back and safety. Jay Ajayi was placed on injured reserve this week with a torn ACL, and Sproles remains sidelined with a hamstring issue. The good news is that Corey Clement (quad) is good to go after practicing in full this week. He’ll pair with Wendell Smallwood to handle the bulk of the team’s snaps at running back. At safety, Rodney McLeod is also on injured reserve, and with Graham out, that means fourth-round rookie Avonte Maddox is set to play a large role again this week after being on the field for every defensive snap last week in a loss to the Vikings.

The Giants will have to make do another week without Engram, who returned to limited practice early in the week but missed Wednesday’s session before being ruled out. Compounding the issue at the position is that Ellison, who has been filling in, is no lock to play either after limited practices on Tuesday and Wednesday. Scott Simonson, who has two catches since entering the league in 2014, would be the next man up.

One player the Giants will have is pass rusher Olivier Vernon, who is set to make his season debut after missing the first five games of the season with an ankle injury.

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Wednesday’s injury reports

Cardinals at Vikings (-10.5)

Analysis to come.

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Chargers (-1) at Browns

Browns receiver Rashard Higgins was unable to practice after suffering a knee injury on Wednesday. That could mean more targets for rookie Antonio Callaway or Derrick Willies, who emerged late in the team’s OT win over the Ravens. Defensive backs Damarious Randall (heel) and E.J. Gaines (groin) were among four Browns limited.

Bears (-3) at Dolphins

Defensive end Cameron Wake (ankle), corner Bobby McCain (knee) and safety T.J. McDonald (foot) were the three Dolphins who didn’t practice Wednesday due to injury. Six were limited, including left tackle Laremy Tunsil (concussion) and receivers DeVante Parker (quad) and Jakeem Grant (shoulder). The Grant injury would also be a big blow for the return game if he can’t go Sunday.

Panthers at Redskins (-1)

Greg Olsen was a limited participant in practice on Wednesday as he looks to return from a multi-week foot injury. The Panthers tight end had just two catches for 33 yards before fracturing his foot in Week 1. Center Ryan Kalil (neck) practiced in full. Defensive tackle Kawaan Short missed practice with an ankle injury. The Panthers are also set to get Thomas Davis back from suspension this week.

Colts at Jets (-2.5)

Eleven Colts players missed practice on Wednesday, but not tackle Anthony Castonzo (hamstring) and running back Marlon Mack (hamstring), who both practiced in full. Among the DNPs were receiver T.Y. Hilton (chest, hamstring), tight ends Jack Doyle (hip) and Eric Ebron (shin, quad, ankle, knee) and rookie linebacker Darius Leonard (ankle). Running back Isaiah Crowell (ankle) was one of seven Jets players to miss practice on Wednesday after rushing for 219 yards on 15 carries in Week 5. Other absences include cornerbacks Trumaine Johnson (quad) and Buster Skrine (concussion). Wide receiver Terrelle Pryor (groin) was one of three limited Jets.

Steelers at Bengals (-2.5)

Steelers safety Morgan Burnett (groin) remained sidelined on Wednesday after missing the last three games. Linebacker Vince Williams practiced in full and looks likely to return after missing Week 5 with a hamstring injury. Bengals guard Clint Boling (hip) joined rookie center Billy Price (foot) as non-participants in Wednesday’s practice, which could shake up the Bengals’ offensive line. Running back Giovani Bernard (knee) also remained sidelined. Receiver John Ross (groin) was limited to start the week, as were four defenders, including defensive ends Michael Johnson (knee) and Carl Lawson (ankle).

Buccaneers at Falcons (-3.5)

Falcons running back Devonta Freeman returned to game action this week but sustained a new foot injury during the game, which caused him to miss practice on Wednesday. Defensive tackle Grady Jarrett (ankle) also remained sidelined, while receiver Mohamed Sanu (hip) was one of three players limited.

Seahawks (-3) vs. Raiders in London

Analysis to come.  

Bills at Texans (-9.5)

The only players to miss Bills practice were listed as resting, leaving the team with only three injuries to worry about, all in the secondary. Cornerback Tre’Davious White (ankle) and safeties Micah Hyde (groin) and Rafael Bush (shoulder) all managed a limited practice. Texans edge rusher Jadeveon Clowney missed practice on Wednesday due to illness, but most of the team’s injured players managed at least a limited session, including quarterback Deshaun Watson (chest), running back Lamar Miller (chest) and receivers DeAndre Hopkins (foot), Will Fuller (hamstring) and Keke Coutee (hamstring).

Rams (-7) at Broncos

Analysis to come.  

Jaguars (-3) at Cowboys

Jaguars running back Leonard Fournette (hamstring) has already been ruled out for Week 6, and it’s possible we won’t see him back until after the team’s Week 9 bye. The Jaguars continue to deal with O-line injuries, with four players either limited or DNP on Wednesday. The D-line could also be an issue, as Malik Jackson (back) didn’t practice while Calais Campbell (ankle) and Yannick Ngakoue (shoulder) were limited. Cowboys defensive end DeMarcus Lawrence (shoulder) joined linebacker Sean Lee (hamstring) as non-participants in practice on Wednesday, though Lawrence figures to have the better chance of playing this week. Left tackle Tyron Smith (ankle) was one of four Cowboys limited.

Ravens (-3) at Titans

Four Ravens players missed Wednesday’s practice due to injury, all on defense, including defensive tackle Michael Pierce (foot) and corner Brandon Carr (knee). Linebacker Tim Williams (hamstring) was one of two players limited. Titans left tackle Taylor Lewan was held out of practice while recovering from a foot injury, and safety Kenny Vaccaro (elbow) was also a DNP. Linebacker Wesley Woodyard was a limited participated Wednesday after missing Week 5 with a shoulder injury.

Chiefs at Patriots (-3.5)

Analysis to come.  

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